EVALUATION OF ANTIDEPRESSANT ACTIVITY OF TRAMADOL AND TRAMADOL PLUS IMIPRAMINE USING RESERPINE INDUCED HYPOTHERMIA MODEL ON EXPERIMENTAL ANIMALS
The present study was carried out to evaluated antidepressant activity of Tramadol and Tramadol plus Imipramine in experimental animals by using Reserpine Induced Hypothermia Test. Standard drug used in tests was Imipramine (10 mg/kg p.o.). It is a tricyclic antidepressant and it is a monoamine reuptake inhibitor. It inhibits the reuptake of noradrenalin and serotonin (5-HT) by monoaminergic nerve terminals, and thus it facilitates transmission. So, the possible mechanism of Tramadol and combination of Tramadol and Imipramine to decrease the immobility time may be due to the inhibition of monoamine reuptake. These models suggest that Tramadol and combination of Tramadol and Imipramine increases availability of biogenic amines Hence, Tramadol may produces antidepressant due to inhibition of reuptake of noradrenalin and 5-HT (serotonin).