ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITIES OF ETHANOLIC EXTRACTS OF CASSIA SOPHERA (L.) IN ALLOXAN INDUCED DIABETES MICE
Chand Sultana Khatun
Department of Pharmacy, Bangladesh University, Dhaka-1207, Bangladesh
Bytul Mokardesh Rahman
Department of Pharmacy, Rajshahi University, Rajshahi-6205, Bangladesh
Naznin Ara Khatun
Department of Pharmacy, Rajshahi University, Rajshahi-6205, Bangladesh
A.K. Azad
Department of Pharmacy, Bangladesh University, Dhaka-1207, Bangladesh
Ashraf Ali
Department of Pharmacy, Southeast University, Dhaka-1212, Bangladesh
Mir Imam Ibne Wahed
Department of Pharmacy, Rajshahi University, Rajshahi-6205, Bangladesh
The aim of the investigation was to investigate the hypoglycemic and hypolipidemic activity of ethanolic extracts of different parts (fruits and stems) from the plant Cassia sophera in alloxan-‘,induced diabetic mice. 20 mice were used for a week-long anti-hyperglycemic test. Lipid profile analysis was performed by estimating total cholesterol (TC), triglyceride (TG), phospholipid and liver glycogen concentration on 20 mice after week -long antihyperglycemic tested mice. Metformin Hcl (150mg/kg body weight, op. ) was used as a standard antidiabetic agent. The result indicated that after oral ingestion of Cassia sophera(CS) extracts for seven days in diabetic mice, Group-DCF and Group-DCS mice showed significantly (p<0.05) reduced bloodglucose levels 47.23% and62.13% respectively at the dose 300 mg/kg body weight when compared to Group -DC mice. Short-term treatment with extracts had no effect on body weight to organ weight ratio; however, it significantly lowered liver weight in Group DCF and Group-DCS. Administration of extracts greatly reduced both the serum cholesterol and triglycerides and phospholipids levels in Group-DCF and Group-DCS. Liver glycogen content significantly restored in Group-DCF and Group-DCS compared to Group-DC mice. The present investigation established the pharmacological evidence to support the folklore claim and that the plant parts have anti-diabetic and hypo-lipidemic potential.
5 , 2 , 2015
70 - 75