133OVERVIEW OF Cissus quadrangularisFrom the ancient ages plants have been contributing major source for treatments to human diseases. The medicinal plants have gain the remarkable attention, because of its potential pharmacological effects and lesser side effects comparatively than synthetic medicine, so this current World mainly focus on the plant research, Active molecule isolation and findings of phytomedicine. Lots of Indian system of medicine related literatures gave evidence for the herbal medicine and its treatment procedure, but it may not justified by scientifically so this collective information may give some ideas for the research work, this review discussed about vernacular names, Morphology, Botanical distribution, Standardization parameters, Formulations and dosage forms, Chemical constituents, Drug interactions, Side effects, Pharmacological activity of Cissus quadrangularisahmdmueen96@gmail.comReview1222022Cissus quadrangularis,Ethnobotany,Chemical constituents,Drug interactions,Standardization parametersAhamed Mueen Mubeen,Vasuki K,Atchaya A,Ilakiya S,Rasitha Banu U,Rojamani K,Vijayalakshmi SFaculty, Department of Pharmacognosy, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode.,Faculty, Department of Pharmacognosy, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode.,UG Scholar, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode.,UG Scholar, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode.,UG Scholar, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode.,UG Scholar, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode.,UG Scholar, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode.